Rhea Amoxicillin Dosage/Direction for Use

Adults and children over 40 kg: Standard adult dosage: 250 mg 3 times daily, increasing to 500 mg 3 times daily for more severe infections.
High dosage therapy (maximum recommended oral dosage 6 g daily in divided doses): A dosage of 3g twice daily is recommended in appropriate cases for the treatment of severe or recurrent purulent infection of the respiratory tract.
Short course therapy: Simple acute urinary tract infection: two 3 g doses with 10 to 12 hours between the doses. Dental abscess: two 3 g doses with 8 hours between the doses. Gonorrhoea: single 3 g dose.
Eradication of H. Pylori: Amoxicillin 750 mg to 1 g twice daily in combination with a proton pump inhibitor (e.g. omeprazole, lansoprazole) and another antibiotic (e.g. clarithromycin, metrinodazole) for 7 days.
Children under 40 kg: Standard children's dosage: 125 mg 3 times daily, increasing to 250 mg 3 times daily for more severe infections. Amoxicillin 100mg/mL Powder for Suspension (Oral Drops) is recommended for children under 6 months of age. Acute otitis media: 750 mg twice a day for 2 days may be used as an alternative course of treatment.
Patients with renal impairment: In renal impairment the excretion of the antibiotic will be delayed and, depending on the degree of impairment, it may be necessary to reduce the total daily dosage according to the following scheme: Adults and Children over 40 kg: Mild impairment (creatinine clearance greater than 30 ml/min): No change in dosage.
Moderate impairment (creatinine clearance 10 to 30 ml/min): 500 mg twice a day maximum.
Severe impairment (creatinine clearance less than10 ml/min): 500 mg/day maximum.
Children under 40 kg: Mild impairment (creatinine clearance greater than 30 ml/min): No change in dosage.
Moderate impairment (creatinine clearance 10 to 30 ml/min): 15 mg/kg twice a day (maximum 500 mg/twice daily)
Severe impairment (creatinine clearance less than 10 ml/min): 15 mg/kg once a day (maximum 500 mg)
Patients receiving peritoneal dialysis: Amoxicillin maximum 500 mg/day. Dosing as for patients with severe renal impairment (creatinine clearance less than 10 ml/min). Amoxicillin is not removed by peritoneal dialysis.
Patients receiving haemodialysis: Dosing as for patients with severe renal impairment (creatinine clearance less than 10 ml/min).
Amoxicillin is removed from the circulation by haemodialysis. Therefore, 1 additional dose (500 mg for adults or 15 mg/kg for children under 40 kg) may be administered during dialysis and at the end of each dialysis.
PROPHYLAXIS OF ENDOCARDITIS: (see Table 2.)

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Parenteral therapy is indicated if the oral route is considered impracticable or unsuitable, and particularly for the urgent treatment of severe infection.